PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

BTK

Upstream kinases that phosphorylate BTK

LYN

Substrates of BTK

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by BTK.

ABI2ATF6BMXCAMKK1CCM2CDK9CHGBCOBRA1DDEFL1EIF4A3
FGRFUSIP1GTF2IHCLS1HES1HNRPKHTATIPITKMAPK1MAPK12
MAPK8MBNL3MDM2NCAPGNFATC3NFKBIANRIP2OTUD7BPDCD2PER3
PLCG2PPP1R13LPPP2R1APRKACAPRKACBRAD23BRAD51RPS6KA2SLC4A1APSMAD3
SMPXSTAT5BTECTGFB1I1WASWWP1WWTR1ZNF397ZNF655ZW10
ZYX

The phosphorylation motif of BTK

click the image for details

The sequence of BTK

Amino acids in red are phosphorylation sites determined by MS/MS
MAAVILESIF LKRSQQKKKT SPLNFKKRLF LLTVHKLSYY EYDFERGRRG 50
SKKGSIDVEK ITCVETVVPE KNPPPERQIP RRGEESSEME QISIIERFPY 100
PFQVVYDEGP LYVFSPTEEL RKRWIHQLKN VIRYNSDLVQ KYHPCFWIDG 150
QYLCCSQTAK NAMGCQILEN RNGSLKPGSS HRKTKKPLPP TPEEDQILKK 200
PLPPEPAAAP VSTSELKKVV ALYDYMPMNA NDLQLRKGDE YFILEESNLP 250
WWRARDKNGQ EGYIPSNYVT EAEDSIEMYE WYSKHMTRSQ AEQLLKQEGK 300
EGGFIVRDSS KAGKYTVSVF AKSTGDPQGV IRHYVVCSTP QSQYYLAEKH 350
LFSTIPELIN YHQHNSAGLI SRLKYPVSQQ NKNAPSTAGL GYGSWEIDPK 400
DLTFLKELGT GQFGVVKYGK WRGQYDVAIK MIKEGSMSED EFIEEAKVMM 450
NLSHEKLVQL YGVCTKQRPI FIITEYMANG CLLNYLREMR HRFQTQQLLE 500
MCKDVCEAME YLESKQFLHR DLAARNCLVN DQGVVKVSDF GLSRYVLDDE 550
YTSSVGSKFP VRWSPPEVLM YSKFSSKSDI WAFGVLMWEI YSLGKMPYER 600
FTNSETAEHI AQGLRLYRPH LASEKVYTIM YSCWHEKADE RPTFKILLSN 650
ILDVMDEES

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