PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

EIF2AK2

Upstream kinases that phosphorylate EIF2AK2

CHEK2CSNK1ECSNK2A2FYNGSK3BIKBKBMAP3K13MAPK1MAPK9PDPK1
PIM1PRKCIPRKCQRAF1RIPK3TYK2

Substrates of EIF2AK2

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by EIF2AK2.

CHEK2EIF2S1NFKBIAPLK1PRKCDTP53

The phosphorylation motif of EIF2AK2

click the image for details

The sequence of EIF2AK2

sites with predicted upstream kinases:
S83(MAPK1,MAPK9)
T88(GSK3B,IKBKB)
T89(IKBKB)
T90(CHEK2)
Y162(TYK2)
S438(CSNK1E)
T451(CSNK1E,PRKCQ)
S456(MAPK1,PIM1,RAF1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MAGDLSAGFF MEELNTYRQK QGVVLKYQEL PNSGPPHDRR FTFQVIIDGR 50
EFPEGEGRSK KEAKNAAAKL AVEILNKEKK AVSPLLLTTT NSSEGLSMGN 100
YIGLINRIAQ KKRLTVNYEQ CASGVHGPEG FHYKCKMGQK EYSIGTGSTK 150
QEAKQLAAKL AYLQILSEET SVKSDYLSSG SFATTCESQS NSLVTSTLAS 200
ESSSEGDFSA DTSEINSNSD SLNSSSLLMN GLRNNQRKAK RSLAPRFDLP 250
DMKETKYTVD KRFGMDFKEI ELIGSGGFGQ VFKAKHRIDG KTYVIKRVKY 300
NNEKAEREVK ALAKLDHVNI VHYNGCWDGF DYDPETSDDS LESSDYDPEN 350
SKNSSRSKTK CLFIQMEFCD KGTLEQWIEK RRGEKLDKVL ALELFEQITK 400
GVDYIHSKKL IHRDLKPSNI FLVDTKQVKI GDFGLVTSLK NDGKRTRSKG 450
TLRYMSPEQI SSQDYGKEVD LYALGLILAE LLHVCDTAFE TSKFFTDLRD 500
GIISDIFDKK EKTLLQKLLS KKPEDRPNTS EILRTLTVWK KSPEKNERHT 550
C

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