PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

FGR

Upstream kinases that phosphorylate FGR

ACVR1AKT1BTKCDK5CDK7CSKGSK3BJAK2LCKMAPK1
MAPK15MATKPAK1PDPK1PRKCZPTK2PTK2BPXKRPS6KB1SCYL2
STK38LSYKTGFBR2TYRO3ZAP70

Substrates of FGR

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by FGR.

ANXA1ASCC1BCL3CBLCRKCSNK2A1CTTNDDEF2EIF4A3EIF4B
ENO1ETS1HCLS1HNRPKKHDRBS1MAPK1MDM4NCLNCOA2NFATC4
NPM1POLR1CQKIRBBP5RXRARXRGSFRS1SRFTRIM24TRIP10
TRIP6YWHAHZAP70ZYX

The phosphorylation motif of FGR

click the image for details

The sequence of FGR

sites with predicted upstream kinases:
S27(ACVR1,SCYL2)
Y34(JAK2,LCK,MATK,TYRO3)
Y180(PTK2B)
Y412(JAK2,LCK,MATK)
Y523(CSK,TYRO3)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MGCVFCKKLE PVATAKEDAG LEGDFRSYGA ADHYGPDPTK ARPASSFAHI 50
PNYSNFSSQA INPGFLDSGT IRGVSGIGVT LFIALYDYEA RTEDDLTFTK 100
GEKFHILNNT EGDWWEARSL SSGKTGCIPS NYVAPVDSIQ AEEWYFGKIG 150
RKDAERQLLS PGNPQGAFLI RESETTKGAY SLSIRDWDQT RGDHVKHYKI 200
RKLDMGGYYI TTRVQFNSVQ ELVQHYMEVN DGLCNLLIAP CTIMKPQTLG 250
LAKDAWEISR SSITLERRLG TGCFGDVWLG TWNGSTKVAV KTLKPGTMSP 300
KAFLEEAQVM KLLRHDKLVQ LYAVVSEEPI YIVTEFMCHG SLLDFLKNPE 350
GQDLRLPQLV DMAAQVAEGM AYMERMNYIH RDLRAANILV GERLACKIAD 400
FGLARLIKDD EYNPCQGSKF PIKWTAPEAA LFGRFTIKSD VWSFGILLTE 450
LITKGRIPYP GMNKREVLEQ VEQGYHMPCP PGCPASLYEA MEQTWRLDPE 500
ERPTFEYLQS FLEDYFTSAE PQYQPGDQT

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