PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

GSK3B

Upstream kinases that phosphorylate GSK3B

MAP2K1MAPK1MAPK3

Substrates of GSK3B

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by GSK3B.

ABI2APPASCC1BCL3CCND3CCNE1CDKN1ACSDC2CSRP3CTTN
DPYSL2DPYSL3EIF2AK2ESR1FGRGPBP1L1GYS1HCLS1HLCSHNRPD
HNRPKMAPTMKI67IPMTA1MUC1MYCNACANEUROD1NFKB1OTUD7B
POP7PPP1R13LPPP1R2PRKACBPRKAR1APSEN1PSPC1PTENRAP1GAPRELA
RSBN1SMARCC2SMPXSNAI1SNRP70TRIP10UBE2AZHX1ZYX

The phosphorylation motif of GSK3B

click the image for details

The sequence of GSK3B

sites with predicted upstream kinases:
T43(MAPK1,MAPK3)
Y216(MAP2K1)
S219(MAP2K1)
T275(MAPK1,MAPK3)
T403(MAPK1,MAPK3)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MSGRPRTTSF AESCKPVQQP SAFGSMKVSR DKDGSKVTTV VATPGQGPDR 50
PQEVSYTDTK VIGNGSFGVV YQAKLCDSGE LVAIKKVLQD KRFKNRELQI 100
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK 150
QTLPVIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PDTAVLKLCD 200
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL 250
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP 300
WTKDSSGTGH FTSGVRVFRP RTPPEAIALC SRLLEYTPTA RLTPLEACAH 350
SFFDELRDPN VKLPNGRDTP ALFNFTTQEL SSNPPLATIL IPPHARIQAA 400
ASTPTNATAA SDANTGDRGQ TNNAASASAS NST

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