PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

HLCS

Upstream kinases that phosphorylate HLCS

ABL2BMPR1ABMXCAMKK1CDK4CDK6CLK2CLK3CSNK1G2DYRK2
EEF2KEIF2AK1EPHA3EPHB1FGFR1FYNGRK5GSK3BHCKITK
LIMK2LYNMAP2K7MAP3K14MAP4K2MAPK1MAPK10MAPK12MAPK14MAPKAPK3
MAST1MATKMKNK1MYO3ANEK11NEK2NEK6NEK7NLKNPR2
NRBP1PDPK1PIM1PKN1PKN3PNCKPRKACAPRKACBPRKCDPRKCZ
PTK2BRAF1RIPK2RIPK3RPS6KA4RPS6KA5RPS6KB1SCYL2SRPK1STK24
STK25STK3STK36STK38STK40SYKTBK1TGFBR2TNNI3KTRIB2
TSSK2UHMK1WNK1YES1ZAP70

The sequence of HLCS

sites with predicted upstream kinases:
S79(BMPR1A,CLK2,CLK3,MAPKAPK3,PIM1,PKN1,PRKACA,PRKCD,RAF1,RIPK2,RPS6KA5,RPS6KB1,STK38,TRIB2)
T146(STK24)
S147(CDK4,CDK6,MAPK10,MAPK12,NRBP1,RIPK3)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MEDRLHMDNG LVPQKIVSVH LQDSTLKEVK DQVSNKQAQI LEPKPEPSLE 50
IKPEQDGMEH VGRDDPKALG EEPKQRRGSA SGSEPAGDSD RGGGPVEHYH 100
LHLSSCHECL ELENSTIESV KFASAENIPD LPYDYSSSLE SVADETSPER 150
EGRRVNLTGK APNILLYVGS DSQEALGRFH EVRSVLADCV DIDSYILYHL 200
LEDSALRDPW TDNCLLLVIA TRESIPEDLY QKFMAYLSQG GKVLGLSSSF 250
TFGGFQVTSK GALHKTVQNL VFSKADQSEV KLSVLSSGCR YQEGPVRLSP 300
GRLQGHLENE DKDRMIVHVP FGTRGGEAVL CQVHLELPPS SNIVQTPEDF 350
NLLKSSNFRR YEVLREILTT LGLSCDMKQV PALTPLYLLS AAEEIRDPLM 400
QWLGKHVDSE GEIKSGQLSL RFVSSYVSEV EITPSCIPVV TNMEAFSSEH 450
FNLEIYRQNL QTKQLGKVIL FAEVTPTTMR LLDGLMFQTP QEMGLIVIAA 500
RQTEGKGRGG NVWLSPVGCA LSTLLISIPL RSQLGQRIPF VQHLMSVAVV 550
EAVRSIPEYQ DINLRVKWPN DIYYSDLMKI GGVLVNSTLM GETFYILIGC 600
GFNVTNSNPT ICINDLITEY NKQHKAELKP LRADYLIARV VTVLEKLIKE 650
FQDKGPNSVL PLYYRYWVHS GQQVHLGSAE GPKVSIVGLD DSGFLQVHQE 700
GGEVVTVHPD GNSFDMLRNL ILPKRR

Links

NCBI | HGNC | Ensembl | OMIM |
Protein Search Site Search Path Search Network Search