PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

LCK

Upstream kinases that phosphorylate LCK

MAPK1MAPK3

Substrates of LCK

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by LCK.

CBLCD28CD33CD5CTTNDAPP1ERFESR1ETS1EZR
FGRHDAC8HNRPKIL2RBIRAK1ITKKLHL25MAPK12MBNL3MTA1
MXD1NFKBIAPINX1PLCG2PRKCQPTENPTPN6RPA2SH2B3SHC1
SIGLEC10SLAMF1SMAD4SMARCC2SOCS3SPTAN1TRIM16TRIP10TSC22D3VAV1
VAV2VDRVHLWWP1ZAP70ZYX

The phosphorylation motif of LCK

click the image for details

The sequence of LCK

sites with predicted upstream kinases:
S59(MAPK1,MAPK3)
S194(MAPK1,MAPK3)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MGCGCSSHPE DDWMENIDVC ENCHYPIVPL DGKGTLLIRN GSEVRDPLVT 50
YEGSNPPASP LQDNLVIALH SYEPSHDGDL GFEKGEQLRI LEQSGEWWKA 100
QSLTTGQEGF IPFNFVAKAN SLEPEPWFFK NLSRKDAERQ LLAPGNTHGS 150
FLIRESESTA GSFSLSVRDF DQNQGEVVKH YKIRNLDNGG FYISPRITFP 200
GLHELVRHYT NASDGLCTRL SRPCQTQKPQ KPWWEDEWEV PRETLKLVER 250
LGAGQFGEVW MGYYNGHTKV AVKSLKQGSM SPDAFLAEAN LMKQLQHQRL 300
VRLYAVVTQE PIYIITEYME NDTLLDSQLE EKGLGASPWG NLGQQLLLLP 350
TGSLVDFLKT PSGIKLTINK LLDMAAQIAE GMAFIEERNY IHRDLRAANI 400
LVSDTLSCKI ADFGLARLIE DNEYTAREGA KFPIKWTAPE AINYGTFTIK 450
SDVWSFGILL TEIVTHGRIP YPGMTNPEVI QNLERGYRMV RPDNCPEELY 500
QLMRLCWKER PEDRPTFDYL RSVLEDFFTA TEGQYQPQP

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