PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

MAPK1

Upstream kinases that phosphorylate MAPK1

ACVR1BBTKCAMK2DCSNK1DDCLK1DYRK1BFGFR4FGRHIPK1MAP2K1
MAP2K3MAPK14MAPK8MAPKAPK5RIPK3RPS6KA1RPS6KA5SCYL2SRPK2STK16
TBK1WNK1YES1

Substrates of MAPK1

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by MAPK1.

APBB1BCL2L11CADCAPN2CASP9CDKN1BCEBPACLK3CSNK1G2CSRP3
CTTNDAPK1DDEFL1DUSP1DUSP16DUSP6EGFREIF2AK2ERFESPL1
FGRFOSGAB1GADD45AGRB10GSK3BHLCSIL16LCKLIFR
MAP2K1MAPKAPK2MAPKAPK5MBPMCL1MDM2MDM4MED1MED28MTA1
MYCNCOA1NFATC4NUP133OTUD7BPAK1PGRPHF17PITPNM1PLA2G4A
POLR2APPARGPPP1R13LPRKAR1ARAD23BRAD51RELARGS19RNH1RPS3
RPS6KA5RXRASH2B1SMAD1SMAD3SMC3SOS1SOX10SP1SREBF1
SREBF2SRXN1STAT5ASTK16THRBTOP2ATP53TSC2TSC22D3UBE2A
UBTFZBED1

The phosphorylation motif of MAPK1

click the image for details

The sequence of MAPK1

sites with predicted upstream kinases:
T63(MAP2K1,MAP2K3)
T181(WNK1)
T185(MAP2K1,MAP2K3)
Y187(DYRK1B,MAP2K1,MAP2K3)
T190(DCLK1)
S202(WNK1)
Y205(MAP2K1,MAP2K3)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MAAAAAAGAG PEMVRGQVFD VGPRYTNLSY IGEGAYGMVC SAYDNVNKVR 50
VAIKKISPFE HQTYCQRTLR EIKILLRFRH ENIIGINDII RAPTIEQMKD 100
VYIVQDLMET DLYKLLKTQH LSNDHICYFL YQILRGLKYI HSANVLHRDL 150
KPSNLLLNTT CDLKICDFGL ARVADPDHDH TGFLTEYVAT RWYRAPEIML 200
NSKGYTKSID IWSVGCILAE MLSNRPIFPG KHYLDQLNHI LGILGSPSQE 250
DLNCIINLKA RNYLLSLPHK NKVPWNRLFP NADSKALDLL DKMLTFNPHK 300
RIEVEQALAH PYLEQYYDPS DEPIAEAPFK FDMELDDLPK EKLKELIFEE 350
TARFQPGYRS

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