PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

MAPK8

Upstream kinases that phosphorylate MAPK8

ACVR1BAKT1BTKCSNK1DDYRK1BFGFR4GRK6MAP2K4MAP2K7MAPK3
MAPK7MAPKAPK5MYLK2PLK1PRKAA1PRKAA2RIPK2TGFBR2

Substrates of MAPK8

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by MAPK8.

APBB1APLP2ATF2ATF7ATN1BCL2BCL2L1BRCA1CENTD2DDEF2
DYRK1BEDF1EIF4A2ELK1ERFETV1FBLFBXO3FOSL1FOXO4
HNRPKHSF1HTATIPIRS1JUNKRT8LZTS1MAPK1MAPK12MAPK8IP1
MDM4MITFMTF2NCLNCOA4NPM1PPARAPPARGPPP1R13LPPP2R1A
RCHY1RNH1RPA1RPA2RUVBL2RXRASF3B1SFNSMAD3SMAD4
SNRP70SRFSTUB1SUMO1SUMO3SUMO4TRIM24TRIM28TRIP6UBE2A
VDAC1XPAXPO1XRCC4YWHABYWHAEYWHAHYWHAZZBTB16ZHX1
ZNF385

The phosphorylation motif of MAPK8

click the image for details

The sequence of MAPK8

sites with predicted upstream kinases:
S155(DYRK1B)
T183(MAP2K4,MAP2K7,MAPK3)
Y185(DYRK1B,MAP2K4,MAP2K7)
T258(PRKAA2)
Y259(DYRK1B,FGFR4,MAP2K4)
T367(ACVR1B,MYLK2)
S377(MAPK7)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER 50
NVAIKKLSRP FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE 100
FQDVYIVMEL MDANLCQVIQ MELDHERMSY LLYQMLCGIK HLHSAGIIHR 150
DLKPSNIVVK SDCTLKILDF GLARTAGTSF MMTPYVVTRY YRAPEVILGM 200
GYKENVDLWS VGCIMGEMVC HKILFPGRDY IDQWNKVIEQ LGTPCPEFMK 250
KLQPTVRTYV ENRPKYAGYS FEKLFPDVLF PADSEHNKLK ASQARDLLSK 300
MLVIDASKRI SVDEALQHPY INVWYDPSEA EAPPPKIPDK QLDEREHTIE 350
EWKELIYKEV MDLEERTKNG VIRGQPSPLG AAVINGSQHP SSSSSVNDVS 400
SMSTDPTLAS DTDSSLEAAA GPLGCCR

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