PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

MDM2

Upstream kinases that phosphorylate MDM2

ACVR1BTKBUB1CDK5CHEK2CLK2CSNK1A1CSNK1DDYRK2MAPK1
MAPK10MAPK9MAPKAPK5NEK3NEK9NPR2PAK6PDPK1PNCKPRKAA2
PRKCIRPS6KA2RPS6KA4RPS6KB1SCYL2SRPK1SRPK2STK17ASTK38SYK
TBK1TGFBR2TNK2TNNI3KWEE1

The sequence of MDM2

sites with predicted upstream kinases:
S157(CHEK2,CSNK1D,RPS6KA4)
S160(SRPK1,SRPK2,STK38)
S166(BUB1,PNCK,PRKAA2,RPS6KB1,SRPK1,SRPK2,STK38)
S186(CHEK2,NEK3,RPS6KB1,SRPK1,SRPK2,STK38)
S188(SRPK1,SRPK2)
S240(CSNK1A1,NEK3,STK38,TNNI3K)
S242(NEK3)
S246(PNCK)
S260(PAK6,PNCK,PRKAA2,RPS6KA2,STK17A,TBK1)
S262(BUB1,CLK2,CSNK1A1,PRKCI,STK38)
S269(ACVR1,BUB1,NEK3)
S395(NEK9,PDPK1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MCNTNMSVPT DGAVTTSQIP ASEQETLVRP KPLLLKLLKS VGAQKDTYTM 50
KEVLFYLGQY IMTKRLYDEK QQHIVYCSND LLGDLFGVPS FSVKEHRKIY 100
TMIYRNLVVV NQQESSDSGT SVSENRCHLE GGSDQKDLVQ ELQEEKPSSS 150
HLVSRPSTSS RRRAISETEE NSDELSGERQ RKRHKSDSIS LSFDESLALC 200
VIREICCERS SSSESTGTPS NPDLDAGVSE HSGDWLDQDS VSDQFSVEFE 250
VESLDSEDYS LSEEGQELSD EDDEVYQVTV YQAGESDTDS FEEDPEISLA 300
DYWKCTSCNE MNPPLPSHCN RCWALRENWL PEDKGKDKGE ISEKAKLENS 350
TQAEEGFDVP DCKKTIVNDS RESCVEENDD KITQASQSQE SEDYSQPSTS 400
SSIIYSSQED VKEFEREETQ DKEESVESSL PLNAIEPCVI CQGRPKNGCI 450
VHGKTGHLMA CFTCAKKLKK RNKPCPVCRQ PIQMIVLTYF P 500

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