PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

MDM4

Upstream kinases that phosphorylate MDM4

ACVR1BAKT1ARAFAURKBBUB1CAMKK1CDK3CDK4CDK5CDK6
CDK7CLK1CLK2CSKCSNK1A1CSNK1ECSNK2A1FGRHIPK1LATS1
MAP2K4MAP3K7MAPK1MAPK10MAPK7MAPK8MAPK9NEK6NUAK1PAK1
PAK6PBKPDPK1PIK3C3PRKACAPRKCIPTK2RIOK1RPS6KA5SRPK1
STK4UHMK1WEE1

The sequence of MDM4

sites with predicted upstream kinases:
S161(BUB1,NEK6)
S342(CLK1,MAP2K4)
T365(AURKB,PAK1,PIK3C3,RPS6KA5,SRPK1)
S367(AKT1,NUAK1,PRKACA)
S403(CLK1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MTSFSTSAQC STSDSACRIS PGQINQVRPK LPLLKILHAA GAQGEMFTVK 50
EVMHYLGQYI MVKQLYDQQE QHMVYCGGDL LGELLGRQSF SVKDPSPLYD 100
MLRKNLVTLA TATTDAAQTL ALAQDHSMDI PSQDQLKQSA EESSTSRKRT 150
TEDDIPTLPT SEHKCIHSRE DEDLIENLAQ DETSRLDLGF EEWDVAGLPW 200
WFLGNLRSNY TPRSNGSTDL QTNQDVGTAI VSDTTDDLWF LNESVSEQLG 250
VGIKVEAADT EQTSEEVGKV SDKKVIEVGK NDDLEDSKSL SDDTDVEVTS 300
EDEWQCTECK KFNSPSKRYC FRCWALRKDW YSDCSKLTHS LSTSDITAIP 350
EKENEGNDVP DCRRTISAPV VRPKDAYIKK ENSKLFDPCN SVEFLDLAHS 400
SESQETISSM GEQLDNLSEQ RTDTENMEDC QNLLKPCSLC EKRPRDGNII 450
HGRTGHLVTC FHCARRLKKA GASCPICKKE IQLVIKVFIA

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