PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

MTA1

Upstream kinases that phosphorylate MTA1

AKT1ARAFAURKBAXLBMPR1BBMPR2BMXCDK4CDK5CHEK2
CLK2CSKCSNK1ECSNK2A2DDR1DYRK1BEPHB3FGFR1FGFR2FYN
GSK3BHIPK1IGF1RJAK2KITLCKLYNMAP2K2MAP2K7MAPK1
MAPK10MAPK12MAPK9MAST1MAST2METMKNK1MKNK2NEK2NEK3
NEK4PAK1PAK4PBKPDGFRBPIM1PLK3PRKACBPRKCAPRKCI
PRKCQPRKCZPTK2BPTK6PXKRAF1RPS6KA3RPS6KA4RPS6KA5SGK1
SNRKSRPK1SRPK2STK17ASTK38STK4STK40STYK1SYKTBK1
TNK2TYK2WEE1ZAP70

The sequence of MTA1

sites with predicted upstream kinases:
S56(DYRK1B,PLK3,SRPK2,STK40)
S58(CDK4,CDK5,MAPK1,MAPK10,MAPK12,MAPK9)
S97(NEK4,PBK)
S98(CSNK1E,TBK1)
T100(CDK4,CDK5,MAPK1,MAPK10,MAPK12,MAPK9,MAST1,NEK4)
S112(BMPR2,NEK4,STK17A)
T114(CLK2,HIPK1,PRKCI,PXK,RPS6KA4,SNRK,STK38,WEE1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MKTRQAFYLH TTKLTRIARR LCREILRPWH AARHPYLPIN SAAIKAECTA 50
RLPEASQSPL VLKQAVRKPL EAVLRYLETH PRPPKPDPVK SVSSVLSSLT 100
PAKVAPVINN GSPTILGKRS YEQHNGVDGN MKKRLLMPSR GTYLGLANHG 150
QTRHMGPSRN LLLNGKSYPT KVRLIRGGSL PPVKRRRMNW IDAPDDVFYM 200
ATEETRKIRK LLSSSETKRA ARRPYKPIAL RQSQALPPRP PPPAPVNDEP 250
IVIED

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