PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

NFATC4

Upstream kinases that phosphorylate NFATC4

ACVR1BMPR1BCAMK4CDK4CDK5CDK6CDK7CLK2CSNK2A2DCLK2
DYRK1BDYRK4EEF2KEPHB1FGFR2FGFR4FGRFYNIGF1RITK
MAP3K7MAPK1MAPK14MAPK3MAPKAPK5METMKNK1NEK3NLKPAK1
PAK4PAK6PIM1PRKAA2PRKACAPRKCAPTK6PXKRPS6KA2RPS6KA3
RPS6KA4RPS6KB1SRPK1SRPK2STK3STK36STK38TGFBR2TRIB3UHMK1
VRK1WEE1WNK1

The sequence of NFATC4

sites with predicted upstream kinases:
S168(BMPR1B,CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK14,MAPK3,STK38)
S170(BMPR1B,CDK4,CDK5,CDK6,CDK7,MAPK1,RPS6KA4,WEE1)
S213(CDK4,CDK5,CDK6,CDK7,DYRK1B,MAPK1,MAPK14,MAPK3,SRPK2)
S217(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK14,MAPK3,RPS6KA4,UHMK1,WEE1)
S221(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK14,MAPK3,PRKCA,STK36,VRK1)
Y234(EPHB1,WEE1)
S272(ACVR1,CLK2,NLK,PAK1,PAK4,PIM1,PRKACA,PXK,RPS6KA3,RPS6KB1,SRPK1,STK38,WNK1)
S289(CAMK4,CSNK2A2,MAP3K7,NLK,PAK1,PAK4,PAK6,PIM1,PRKAA2,PRKACA,PRKCA,RPS6KA2,RPS6KA3,RPS6KB1,SRPK2,STK38)
S334(ACVR1,PAK1,PAK4,PIM1,PRKACA,PRKCA,RPS6KA3,RPS6KB1,VRK1)
S676(CDK4,CDK5,CDK6,CDK7,MAPK3,PAK4,PIM1,PRKACA,RPS6KA3,RPS6KB1,SRPK1,SRPK2)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MGAASCEDEE LEFKLVFGEE KEAPPLGAGG LGEELDSEDA PPCCRLALGE 50
PPPYGAAPIG IPRPPPPRPG MHSPPPRPAP SPGTWESQPA RSVRLGGPGG 100
GAGGAGGGRV LECPSIRITS ISPTPEPPAA LEDNPDAWGD GSPRDYPPPE 150
GFGGYREAGG QGGGAFFSPS PGSSSLSSWS FFSDASDEAA LYAACDEVES 200
ELNEAASRFG LGSPLPSPRA SPRPWTPEDP WSLYGPSPGG RGPEDSWLLL 250
SAPGPTPASP RPASPCGKRR YSSSGTPSSA SPALSRRGSL GEEGSEPPPP 300
PPLPLARDPG SPGPFDYVGA PPAESIPQKT RRTSSEQAVA LPRSEEPASC 350
NGKLPLGAEE SVAPPGGSRK EVAGMDYLAV PSPLAWSKAR IGGHSPIFRT 400
SALPPLDWPL PSQYEQLELR IEVQPRAHHR AHYETEGSRG AVKAAPGGHP 450
VVKLLGYSEK PLTLQMFIGT ADERNLRPHA FYQVHRITGK MVATASYEAV 500
VSGTKVLEMT LLPENNMAAN IDCAGILKLR NSDIELRKGE TDIGRKNTRV 550
RLVFRVHVPQ GGGKVVSVQA ASVPIECSQR SAQELPQVEA YSPSACSVRG 600
GEELVLTGSN FLPDSKVVFI ERGPDGKLQW EEEATVNRLQ SNEVTLTLTV 650
PEYSNKRVSR PVQVYFYVSN GRRKRSPTQS FRFLPVICKE EPLPDSSLRG 700
FPSASATPFG TDMDFSPPRP PYPSYPHEDP ACETPYLSEG FGYGMPPLYP 750
QTGPPPSYRP GLRMFPETRG TTGCAQPPAV SFLPRPFPSD PYGGRGSSFS 800
LGLPFSPPAP FRPPPLPASP PLEGPFPSQS DVHPLPAEGY NKVGPGYGPG 850
EGAPEQEKSR GGYSSGFRDS VPIQGITLEE VSEIIGRDLS GFPAPPGEEP 900
PA

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