PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

PAK1

Upstream kinases that phosphorylate PAK1

MAPK1

Substrates of PAK1

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by PAK1.

ABI2ARHGAP20ARHGDIAARHGEF2ARRDC4BCL3BPNT1BRAFBTBD14AC21orf7
CAMKK1CHES1CSAG2CSNK1G2CSRP3CTTNCXXC1DAXXDDEFL1EIF4A3
EIF4HESR1EXOSC5FGRFLNAFOXL2GNAZGRK5HCLS1HNRPK
IRF3KCNIP4LIG1LIMK1LOC93349MAGEA2BMAGEA9MAP2K1MAPK12MAPK7
MAXMBNL3MDFIMDM4MEN1MGC27016MTA1MYLKMYOD1NFATC4
OTUD7BPGAM1PGM1PHB2PPP1R13LPPP2R1APRDM1PRIM2APRKACARAF1
RPS6KA2RUNX1T1SFRS1SMAD3SNAI1SOX10STK16STMN1TRIM16UPK3A
VIMWDR45LZBTB44ZCCHC8ZDHHC11ZHX1ZNF396

The phosphorylation motif of PAK1

click the image for details

The sequence of PAK1

sites with predicted upstream kinases:
T212(MAPK1)
S220(MAPK1)
S223(MAPK1)
T230(MAPK1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MSNNGLDIQD KPPAPPMRNT STMIGAGSKD AGTLNHGSKP LPPNPEEKKK 50
KDRFYRSILP GDKTNKKKEK ERPEISLPSD FEHTIHVGFD AVTGEFTGMP 100
EQWARLLQTS NITKSEQKKN PQAVLDVLEF YNSKKTSNSQ KYMSFTDKSA 150
EDYNSSNALN VKAVSETPAV PPVSEDEDDD DDDATPPPVI APRPEHTKSV 200
YTRSVIEPLP VTPTRDVATS PISPTENNTT PPDALTRNTE KQKKKPKMSD 250
EEILEKLRSI VSVGDPKKKY TRFEKIGQGA SGTVYTAMDV ATGQEVAIKQ 300
MNLQQQPKKE LIINEILVMR ENKNPNIVNY LDSYLVGDEL WVVMEYLAGG 350
SLTDVVTETC MDEGQIAAVC RECLQALEFL HSNQVIHRDI KSDNILLGMD 400
GSVKLTDFGF CAQITPEQSK RSTMVGTPYW MAPEVVTRKA YGPKVDIWSL 450
GIMAIEMIEG EPPYLNENPL RALYLIATNG TPELQNPEKL SAIFRDFLNR 500
CLEMDVEKRG SAKELLQHQF LKIAKPLSSL TPLIAAAKEA TKNNH 550

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