PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

PPP1R13L

Upstream kinases that phosphorylate PPP1R13L

AKT1AURKBBMXBTKBUB1CAMKK1CDK4CDK5CDK6CDK7
CHEK2CLK1CLK2CLK3CSNK1DCSNK1EDDR1FGFR4GSK3BMAP3K7
MAPK1MAPK11MAPK8MAPK9MAPKAPK5NEK2NEK9PAK1PBKPRKAA2
PRKACAPRKCZPTK2RPS6KA4SRPK1STK17ASTK38STK4STK40TBK1
TGFBR2TNK2TNNI3KUHMK1WEE1

The sequence of PPP1R13L

sites with predicted upstream kinases:
S53(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK8,MAPK9,STK17A,TNNI3K)
S81(MAP3K7,PBK,STK40)
S84(AURKB,CDK4,CDK5,CDK6,CDK7,CSNK1D,MAP3K7)
S102(AKT1,CAMKK1,CHEK2,CLK1,PRKACA)
Y109(BMX,FGFR4)
S110(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,PBK,TNNI3K)
S113(CAMKK1,CDK4,CDK5,CDK6,CDK7,CLK2,CSNK1D,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,STK38,STK4)
S119(AURKB,CAMKK1,NEK9,PAK1,RPS6KA4,WEE1)
S120(CDK4,CDK5,CDK6,CDK7,CHEK2,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,PRKACA)
T123(CDK4,CDK5,CDK6,CDK7,CSNK1D,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5)
Y132(WEE1)
S134(CSNK1E,TBK1,UHMK1)
S152(CSNK1E,TBK1,UHMK1)
S158(AKT1,CDK4,CDK5,CDK6,CDK7,CHEK2,MAPK1,MAPK11,MAPK8,MAPK9,PRKACA,RPS6KA4,UHMK1,WEE1)
S183(AKT1,CAMKK1,CDK4,CDK6,CHEK2,CLK2,GSK3B,MAP3K7,MAPK1,MAPK11,MAPK8,MAPK9,PRKACA)
S187(AURKB,CDK4,CDK5,CDK6,CDK7,MAP3K7,MAPK1,MAPK11,MAPK8,MAPK9,PAK1,STK17A,STK40)
Y211(TNK2)
S220(MAP3K7)
S225(MAP3K7,TGFBR2,UHMK1)
T241(CSNK1E,PRKCZ)
S280(AKT1,CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,PRKACA,UHMK1)
T308(CSNK1E,TBK1,TNNI3K)
S316(CDK4,CDK6,CDK7,CLK3,GSK3B,MAPK1,MAPK11)
S332(AURKB,CSNK1E,PAK1,STK17A,TBK1)
T341(CLK1,CSNK1E,GSK3B,MAP3K7,SRPK1,STK40,TBK1,UHMK1)
S357(MAPKAPK5,PBK,RPS6KA4,WEE1)
S358(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,STK17A,STK40,UHMK1)
S395(CDK4,CDK5,CDK6,CDK7,MAP3K7,MAPK1,MAPK11,MAPK8,MAPK9,MAPKAPK5,NEK9,PRKCZ,UHMK1)
T399(PBK,STK40)
S526(AKT1,AURKB,CHEK2,MAP3K7,PAK1,PRKACA)
S567(CDK4,CDK5,CDK6,CDK7,MAPK1,MAPK11,MAPK8,MAPK9,STK17A,STK40)
T570(BUB1,CSNK1D,MAPKAPK5,TNNI3K)
S594(PBK,RPS6KA4,STK40,WEE1)
S597(CDK4,CDK5,CDK6,CDK7,GSK3B,MAPK1,MAPK8,MAPK9,PRKAA2,UHMK1)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MDSEAFQSAR DFLDMNFQSL AMKHMDLKQM ELDTAAAKVD ELTKQLESLW 50
SDSPAPPGPQ AGPPSRPPRY SSSSIPEPFG SRGSPRKAAT DGADTPFGRS 100
ESAPTLHPYS PLSPKGRPSS PRTPLYLQPD AYGSLDRATS PRPRAFDGAG 150
SSLGRAPSPR PGPGPLRQQG PPTPFDFLGR AGSPRGSPLA EGPQAFFSER 200
GPSPRPPATA YDAPASAFGS SLLGSGGSAF APPLRAQDDL TLRRRPPKAW 250
NESDLDVAYE KKPSQTASYE RLDVFARPAS PSLQLLPWRE SSLDGLGGTG 300
KDNLTSATLP RNYKVSPLAS DRRSDAGSYR RSLGSAGPSG TLPRSWQPVS 350
RIPMPPSSPQ PRGAPRQRPI PLSMIFKLQN AFWEHGASRA MLPGSPLFTR 400
APPPKLQPQP QPQPQPQSQP QPQLPPQPQT QPQTPTPAPQ HPQQTWPPVN 450
EGPPKPPTEL EPEPEIEGLL TPVLEAGDVD EGPVARPLSP TRLQPALPPE 500
AQSVPELEEV ARVLAEIPRP LKRRGSMEQA PAVALPPTHK KQYQQIISRL 550
FHRHGGPGPG GPEPELSPIT EGSEARAGPP APAPPAPIPP PAPSQSSPPE 600
QPQSMEMRSV LRKAGSPRKA RRARLNPLVL LLDAALTGEL EVVQQAVKEM 650
NDPSQPNEEG ITALHNAICG ANYSIVDFLI TAGANVNSPD SHGWTPLHCA 700
ASCNDTVICM ALVQHGAAIF ATTLSDGATA FEKCDPYREG YADCATYLAD 750
VEQSMGLMNS GAVYALWDYS AEFGDELSFR EGESVTVLRR DGPEETDWWW 800
AALHGQEGYV PRNYFGLFPR VKPQRSKV

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