PhosphoNetworks

- A database for experimentally determined kinase-substrate relationships

PRKACA

Upstream kinases that phosphorylate PRKACA

AKT1AKT3AURKBBTKCAMK2BCAMK2DCAMK2GCAMKK2CDK9CDKL5
CLK2CSKDDR1DMPKDYRK1BDYRK4FYNHIPK1HIPK4ILK
JAK2KSR2MAPK12MAPK13MAPK7MAPKAPK5MARK3METNLKNUAK1
PAK1PRKAA1PRKAA2PXKRPS6KA5RPS6KB1RPS6KB2SGK2SRPK1SRPK2
STK16TESK2ZAP70

Substrates of PRKACA

Mouseover proteins with red dots for specific sites predicted to be phosphorylated by PRKACA.

ACACAARID3ABADBMI1C13orf15C19orf2C21orf66CAMKK1CBFA2T3CBL
CDCA7LCHAF1BCIAO1CRIP2CSDC2CSDE1CSRP3CTTNDAXXDDEF2
EIF4ENIF1EXOSC5FIP1L1FYNGAS7HCLS1HLCSHNRPKID2IRF3
LARP1LRRFIP1MATR3MDFIMDM4NASPNCOA4NEUROD1NFATC3NFATC4
NPM1NRIP2PHF17PPP1R13LPPP1R8PRDX5PRKAR1APSMA8RBM19RCHY1
RGS14RNUXARUNX1T1RUVBL2RXRASAFB2SIP1SMARCC2SMC3SNUPN
STUB1TAF10TRIM28TRIP10TTF2VHLXPO1XRCC4YWHAEYWHAH
ZHX1ZYX

The phosphorylation motif of PRKACA

click the image for details

The sequence of PRKACA

sites with predicted upstream kinases:
S11(HIPK4,KSR2,PRKAA2)
T49(AKT1,CAMK2B,CAMK2D,CAMK2G,NUAK1,PRKAA1,RPS6KB1,SGK2,TESK2)
S140(AURKB,CAMKK2,DYRK1B,ILK,PAK1,PXK,RPS6KA5,SGK2,SRPK2)
T196(DYRK1B,SGK2,SRPK2)
T198(AKT1,CAMK2B,CAMK2D,CAMK2G,CLK2,HIPK1,NLK,NUAK1,PRKAA1,PXK,RPS6KB1,SGK2,STK16,TESK2)
T202(HIPK4)
Y331(CSK,TESK2,ZAP70)
S339(AURKB,KSR2,PAK1,PRKAA2,RPS6KA5)

Amino acids in red are phosphorylation sites determined by MS/MS
Mouseover sites for predicted upstream kinases
MGNAAAAKKG SEQESVKEFL AKAKEDFLKK WESPAQNTAH LDQFERIKTL 50
GTGSFGRVML VKHKETGNHY AMKILDKQKV VKLKQIEHTL NEKRILQAVN 100
FPFLVKLEFS FKDNSNLYMV MEYVPGGEMF SHLRRIGRFS EPHARFYAAQ 150
IVLTFEYLHS LDLIYRDLKP ENLLIDQQGY IQVTDFGFAK RVKGRTWTLC 200
GTPEYLAPEI ILSKGYNKAV DWWALGVLIY EMAAGYPPFF ADQPIQIYEK 250
IVSGKVRFPS HFSSDLKDLL RNLLQVDLTK RFGNLKNGVN DIKNHKWFAT 300
TDWIAIYQRK VEAPFIPKFK GPGDTSNFDD YEEEEIRVSI NEKCGKEFSE 350
F

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